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哌醋甲酯和托莫西汀治疗注意缺陷多动障碍

Objective: To assess and compare the effectiveness and safety ofmethylphenidate immediate-release tablets (IR-MPH), methylphenidate controlled-release tablets (OROs-MPH) and atomoxetine (AHC) for attention deficit hyperactivity disorder (ADHD) in Chinese children.
 
Methods: Randomized or clinical controlled trials on the effectiveness and safety of IR-MPH, OROS- MPH and AHC for ADHD were searched in electronic databases of CNKI, VIP, CBMDISC online, PubMed,Embase and MEDLNE. Twreviewers independently extracted the data and assessed the quality of the included literatures.
 
Results: Eight trials were finally included. IR-MPH, oROS-MPH and AHC were effective for ADHD. ORos-MPH was superior to IR-MPH in the improvement of peer relationship, CGl-I score, mother satisfaction and psychosomatic problems. There were no significant differencesin the effectiveness between the AHC and IR-MPH group. The adverse events related to the therapy with IR-MPH, OROS-MPH or AHC were mild and totalincidence rates ofadverse events was not signifcantly differentamong the three groups. Conclusions: The effectiveness of oRos-MPH for the treatment ofADHD is probably superior to IR- MPH, and the effectiveness of AHC and IR-MPH is similar. The three drugs have equivalent safety and good tolerance.